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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK1
All Species:
8.18
Human Site:
S516
Identified Species:
15
UniProt:
P57059
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P57059
NP_775490.2
783
84902
S516
L
T
F
S
A
S
K
S
P
A
G
L
S
G
T
Chimpanzee
Pan troglodytes
XP_531484
783
84972
S516
L
T
F
S
A
S
K
S
P
A
G
L
S
G
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_544912
898
97147
P641
T
F
S
A
G
D
G
P
G
A
L
S
G
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q60670
779
85009
G518
L
P
F
S
A
S
E
G
P
A
G
L
G
S
G
Rat
Rattus norvegicus
Q9R1U5
776
84890
G518
L
P
F
S
A
S
E
G
P
A
G
L
G
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511894
801
88312
G523
L
P
S
S
S
T
E
G
S
G
A
L
G
G
R
Chicken
Gallus gallus
Q9IA88
798
88848
S516
L
T
S
S
S
N
D
S
S
V
A
L
S
S
C
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
A568
P
H
P
I
P
A
V
A
P
V
D
E
E
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
G900
S
S
S
G
V
L
A
G
S
A
G
S
Y
S
K
Honey Bee
Apis mellifera
XP_397175
718
80391
S500
P
P
P
P
M
S
P
S
P
I
T
G
R
I
S
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
K726
M
M
S
K
L
I
N
K
T
P
A
A
G
G
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
E297
Q
A
K
K
I
N
E
E
I
V
Q
E
V
V
N
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
Q418
S
Q
S
P
P
T
F
Q
Q
Q
S
K
S
H
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
69.2
N.A.
81.3
81.6
N.A.
70.4
66.6
N.A.
32
N.A.
28.8
36.5
24.5
N.A.
Protein Similarity:
100
99.6
N.A.
73.6
N.A.
86.2
86.3
N.A.
77
76.6
N.A.
44
N.A.
38
50.9
39.4
N.A.
P-Site Identity:
100
100
N.A.
6.6
N.A.
60
66.6
N.A.
26.6
40
N.A.
13.3
N.A.
13.3
20
13.3
N.A.
P-Site Similarity:
100
100
N.A.
13.3
N.A.
66.6
73.3
N.A.
46.6
53.3
N.A.
33.3
N.A.
20
26.6
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.2
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41
42.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
31
8
8
8
0
47
24
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
0
0
0
0
8
8
0
0
0
8
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
31
8
0
0
0
16
8
0
0
% E
% Phe:
0
8
31
0
0
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
8
0
8
31
8
8
39
8
39
47
16
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
8
8
8
0
0
8
8
0
0
0
8
0
% I
% Lys:
0
0
8
16
0
0
16
8
0
0
0
8
0
0
8
% K
% Leu:
47
0
0
0
8
8
0
0
0
0
8
47
0
0
8
% L
% Met:
8
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
16
8
0
0
0
0
0
0
0
8
% N
% Pro:
16
31
16
16
16
0
8
8
47
8
0
0
0
0
0
% P
% Gln:
8
8
0
0
0
0
0
8
8
8
8
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
8
% R
% Ser:
16
8
47
47
16
39
0
31
24
0
8
16
31
24
16
% S
% Thr:
8
24
0
0
0
16
0
0
8
0
8
0
0
0
24
% T
% Val:
0
0
0
0
8
0
8
0
0
24
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _